姓名: 吴华悦
学校: 温州大学
学院: 化学与材料工程学院
职称:  

<div class> <p><br/>   姓名:吴华悦 <br/>   性别:男 <br/>   出生年月:1962年3月 <br/>   职称:教授 <br/>   所在学院:数学与信息科学学院 <br/> <br/>   个人简介<br/> </strong>  吴华悦,男,汉族,1962年3月生,浙江兰溪,中共党员,教授,硕士研究生导师。<br/>   1984毕业于杭州大学化学系有机化学专业,同年进入温州师范学院任教,现任温州大学有机及药物化学研究所所长,有机化学硕士点负责人,浙江省新药创制平台理事会理事,浙江省新药创制科技服务平台温州工作站负责人。<br/>   入选温州市“新世纪551人才工程”第一层次、温州大学“高级人才工程”,获温州大学“教坛名师”称号。<br/>   指导的研究生硕士论文入选2008年度浙江省优秀硕士论文。<br/>   主持和参加国家“十一五”科技支撑计划项目、国家自然科学基金等国家、省部级科研项目多项,已在Org. Lett.; J. Org. Chem.; Green Chem.; Tetraherdon; Synlett; Tetraherdon Lett.; Synthesis等国内外刊物上发表SCI论文60余篇,申请专利20余项,其中授权发明专利4项。<br/>   获浙江省科学技术奖2项,目前正从事药物及中间体的合成研究和有机合成方法学研究,是省、市重大科技项目的评审专家。<br/>   2009年被Encyclopedia of Reagents for Organic Synthesis创刊编辑Leo A. Paquette邀请撰写其中部分章节(Preparation and Application of Tris-1-naphthyl Phosphine),被J. Org. Chem.; Green Chem.和Tetrahedron等期刊选为审稿人。 <br/> <br/>   代表论著 <br/> </strong>  1.Jiuxi Chen,* Yong Peng, Miaochang Liu, Jinchang Ding, Huayue Wu,* Palladium-catalyzed aerobic oxidative coupling of acyl chlorides with arylboronic acids, Adv. Synth. Catal. 2012 accepted. SCI-TOP<br/>   2.Quansheng Ding, Jilei Zhang, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Huayue Wu,* Tandem synthesis of 2,3-dihydroquinazolin-4(1h)-ones on grinding under solvent-free conditions, J. Heterocyclic Chem. 2012, in press. SCI<br/>   3.Gaigai Liang, Miaochang Liu, Jiuxi Chen,* Jinchang Ding, Wenxia Gao, Huayue Wu,* NBS-promoted sulfenylation of sulfinates with disulfides leading to unsymmetrical or symmetrical thiosulfonates, Chin. J. Chem. 2012, in press. SCI<br/>   4.Tieqiang Huang, Jinchang Ding, Miaochang Liu, Wenxia Gao, Huayue Wu, Jiuxi Chen,* Catalyst-free protocol for the synthesis of quinoxalines and pyrazines in PEG, J. Heterocyclic Chem. 2012, in press. SCI<br/>   5.Jilei Zhang, Jiuxi Chen,* Miaochang Liu, Xingwang Zheng, Jinchang Ding, Huayue Wu,* Ligand-free copper-catalyzed coupling of nitroarenes with arylboronic acids, Green Chem. 2012, 14, 912-916. SCI-TOP<br/>   6.Shaojin Gu, Bo Liu, Jiuxi Chen, Huayue Wu,* Wanzhi Chen,* Synthesis, structures, and properties of ruthenium(II) complexes of N-(1,10-phenanthrolin-2-yl)imidazolylidenes, Dalton Trans. 2012, 41, 962-970. SCI-TOP<br/>   7.Hui Xu, Wanzhi Chen,* Jiuxi Chen, Huayue Wu,* Stereoselective synthesis of (Z)-1,2-dithio-1-alkenes via copper-catalyzed thiolation of (Z)-2-bromovinyl sulfides, Sythesis 2012, 380–388. SCI-TOP<br/>   8.Hongjuan Deng, Yujing Fang, Gaowei Chen, Miaochang Liu, Huayue Wu, Jiuxi Chen,* Copper-catalyzed Clauson–Kass pyrroles synthesis in aqueous media, Appl. Organometal. Chem. 2012, 26, 164-167. SCI<br/>   9.Guowei Kang, Jun Jiang,* Hongxin Liu, Huayue Wu,* Asymmetric organocatalytic synthesis of β-hydroxyynones with a quaternary carbon center under aqueous conditions, J. Braz. Chem. Soc., 2012, 23, 5-10. SCI<br/>   10.Xiepeng Lin, Wenxia Gao,* Chenen Li, Jiuxi Chen, Chen Yang, Huayue Wu,* Nano-sized flake carboxymethyl cassava starch as excipient for solid dispersions, Int. J. Pharm. 2012, 423, 435-439. SCI-TOP<br/>   11.Wei Lu, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Wenxia Gao, Huayue Wu,* Palladium-catalyzed decarboxylative coupling of isatoic anhydrides with arylboronic acids, Org. Lett. 2011, 13, 6114-6117. SCI-TOP<br/>   12.Tieqiang Huang, Jun Li, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu,* Silica sulfuric acid (ssa)/peg as a recyclable system for the synthesis of quinoxalines and pyrazines, Synth. Commun. 2011, 41, 3334–3343. SCI<br/>   13.Jilei Zhang, Jiuxi Chen,* Jinchang Ding a, Miaochang Liu, Huayue Wu, Copper-catalyzed arylation of indolin-2,3-ones with arylboronic acids, Tetrahedron 2011, 67, 9347-9351. SCI-TOP<br/>   14.Hanmei Zheng, Jinchang Ding, Jiuxi Chen,* Miaochang Liu, Wenxia Gao, Huayue Wu,* Copper-catalyzed arylation of arylboronic acids with aldehydes, Synlett 2011, 1626-1630. SCI-TOP<br/>   15.Xingwang Zheng, Jinchang Ding, Jiuxi Chen*, Wenxiao Gao, Miaochang Liu, Huayue Wu,* The coupling of arylboronic acids with nitroarenes catalyzed by rhodium. Org. Lett. 2011, 48, 403-406. SCI-TOP<br/>   16.Jun Li, Danna Jiang, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Huayue Wu,* Eco-friendly synthesis of quinoxaline derivatives by grinding under solvent-free conditions. J. Heterocyclic Chem. 2011, 48, 403-406. SCI<br/>   17.Wenxia Gao, Xiaoqing Lin, Xiepeng Lin, Jinchang Ding, Xiaobo Huang, Huayue Wu,* Preparation of nano-sized flake carboxymethyl cassava starch under ultrasonic irradiation. Carbohydr. Polym. 2011, 84, 1413–1418. SCI<br/>   18.Yong Peng, Jiuxi Chen,* Jinchang Ding, Miaochang Liu, Wenxiao Gao, Huayue Wu,* Ligand-free copper-catalyzed arylation of olefins by the Mizoroki–Heck reaction. Synthesis 2011, 213-216. SCI-TOP<br/>   19.Xiepeng Lin, Wenxia Gao*, Xiaobo Huang, Panlong Zang, Jiuxi Chen, Huayue Wu,* Morphology-controlled hollow nanospheres of functionalized dextran by self-assembly in aqueous solution. Carbohydr. Polym. 2010, 82, 460–465. SCI<br/>   20.Qiang Zhang, Jiuxi Chen,* WenxiaGao, Jinchang Ding, Huayue Wu,* Copper-catalyzed one-pot synthesis of propargylamines via C–H activation in PEG. Appl. Organometal. Chem. 2010, 24, 809-812. SCI<br/>   21.Weixing Dan, Hongjuan Deng, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Huayue Wu,* A new odorless one-pot synthesis of thioesters and selenoesters promoted by Rongalite®, Tetrahedron 2010, 66, 7384-7388. SCI-TOP<br/>   22.Wenxue Guo, Guangshu Lv, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Huayue Wu,* Rongalite® and base-promoted cleavage of disulfides and subsequent Michael addition to α,β-unsaturated ketones/esters: an odorless synthesis of β-sulfido carbonyl compounds, Tetrahedron 2010, 66, 2297–2300. SCI-TOP<br/>   23.Xiaoling Xu , Jiuxi Chen*, Wenxia Gao, Huayue Wu,* Jinchang Ding, Weike Su, Palladium-catalyzed hydroarylation of alkynes with arylboronic acids, Tetrahedron 2010, 66,2433–2438. SCI-TOP<br/>   24.Mingtiao Cai, Guangshu Lv, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu,* CAN/I2-catalyzed Chemoselective synthesis of thiosulfonates by oxidation of disulfides or thiols, Chem. Lett. 2010, 39, 368-369. SCI<br/>   25.Shaomiao Lin, Jilei Zhang, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Weike Su, Huayue Wu,* An Approach to Synthesis of Thioesters and Selenoesters Promoted by Rongalite®, J. Braz. Chem. Soc. 2010, 21, 1616-1620. SCI <br/>   26.Xiaoliang Yang, Chunmei Xu, Shaomiao Lin, Jiuxi Chen,*, Jinchang Ding, Huayue Wu,* Weike Su, Eco-friendly synthesis of 2-substituted benzothiazoles catalyzed by cetyltrimethyl ammonium bromide (CTAB) in Water, J. Braz. Chem. Soc. 2010, 21, 37-42. SCI<br/>   27.Shuanghua Cheng, Jiuxi Chen,* Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu,* Oxidative esterification of aldehydes with alcohols and phenols in air, J. Chem. Res. 2010, 130-132. SCI<br/>   28.Yali Xu, Jiuxi Chen, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu,* Solvent-free synthesis of 3,5-di(hetero)aryl-1,2,4-thiadiazoles by grinding of thioamides under oxidative conditions. J. Chem. Res. 2010, 151-153. SCI<br/>   29.Jiuxi Chen, Changfu Zhang, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu,* B2O3/Al2O3 as a new, highly efficient and reusable heterogeneous catalyst for the selective synthesis of β-enamino ketones and esters under solvent-free conditions, J. Braz. Chem. Soc. 2010, 21, 1552-1556. SCI<br/>   30.Hanmei Zheng, Qiang Zhang, Jiuxi Chen, Miaochang Liu, Shuanghua Cheng, Jinchang Ding,* Huayue Wu,* Weike Su, Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes, J. Org. Chem. 2009, 74, 943-945. SCI-TOP<br/>   31.Huilong Xiao, Jiuxi Chen, Miaochang Liu, Dongjian Zhu, Jinchang Ding,* Huayue Wu,* Trichloroisocyanuric acid (TCCA) as a mild and efficient catalyst for the synthesis of 2-arylbenzothiazoles, Chem. Lett. 2009, 38, 170-171. SCI<br/>   32.Bing Zuo, Jiuxi Chen, Miaochang Liu, Huayue Wu,* Weike Su,* Yb(OTf)3-catalyzed synthesis of pyrroles under solvent-free conditions, Chin. Chem. Lett. 2009, 20, 423–426. SCI-E<br/>   33.Bing Zuo, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu,* Weike Su,* Scandium Triflate-catalysed synthesis of N-substituted pyrroles from amine and 2,5-dimethoxytetrahydrofuran, J. Chem. Res. 2009, 14-16. SCI<br/>   34.Dongjian Zhu, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu,* Catalyst and solvent-free synthesis of imidazo[1,2-a]pyridines, J. Braz. Chem. Soc. 2009, 20, 482-487. SCI<br/>   35.Wei Xiong, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu,* Weike Su,* A general and efficient synthesis of pyrazoles catalyzed by Sc(OTf)3 under Solvent-Free Conditions, J. Braz. Chem. Soc. 2009, 20, 367-374. SCI<br/>   36.Tieqiang Huang, Qaing Zhang, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu,* Synthesis of quinoxalines catalysed by cetyltrimethyl ammonium bromide (CTAB) in aqueous media, J. Chem. Res. 2009, 761-765. SCI<br/>   37.Dongjian Zhu, Jiuxi Chen, Dengze Wu, Miaochang Liu, Jinchang Ding, Huayue Wu,* An Efficient, Catalyst- and solvent-free synthesis of imidazo-[1,2-a]pyridines and 2,4-disubstituted thiazoles on grinding, J. Chem. Res. 2009, 84-86. SCI<br/>   38.Wenxue Guo, Jiuxi Chen*, Dengze Wu, Jinchang Ding, Fan Chen, Huayue Wu,* Rongalite® promoted highly regioselective synthesis of β-hydroxy sulfides by ring opening of epoxides with disulfides, Tetrahedron 2009, 65 , 5240–5243. SCI-TOP<br/>   39.Dongjian Zhu, Jiuxi Chen, Huilong Xiao, Miaochang Liu, Jinchang Ding, Huayue Wu,* Efficient and expeditious synthesis of di- and trisubstituted thiazoles in PEG under catalyst-free conditions, Synth. Commun. 2009, 39, 2895–2906. SCI <br/>   40.Jiuxi Chen, Xiaoliang Yang, Miaochang Liu, Huayue Wu,* Jinchang Ding, Weike Su, Approach to synthesis of β-enamino ketones and pyrroles catalyzed by gallium(III) triflate under solvent-free conditions, Synth. Commun. 2009, 39, 4180–4198. SCI<br/>   41.Qiang Zhang, Chunmei Xu, Jiuxi Chen,* Xiaoling Xu, Jinchang Ding, Huayue Wu,* Palladium-catalyzed arylation of arylglyoxals with arylboronic acids, Appl. Organometal. Chem. 2009, 23, 524–526. SCI<br/>   42.Wenxue Guo, Huile Jin, Jiuxi Chen,*, Fan Chen, Jinchang Ding, Huayue Wu,* An Efficient Catalyst-Free Protocol for the Synthesis of Quinoxaline Derivatives under Ultrasound Irradiation, J. Braz. Chem. Soc. 2009, 20, 1674-1679. SCI<br/>   43.Xiaoliang Yang, Yali Xu, Jiuxi Chen*, Jinchang Ding, Huayue Wu,* Weike Su, Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2-disulfanediyldianiline with aldehydes in water, J. Chem. Res. 2009, 682–685. SCI<br/>   44.Huilong Xiao, Jiuxi Chen, Miaochang Liu, Huayue Wu,* Jinchang Ding, An approach to disulfide synthesis promoted by sulfonyl chloride in sodium bicarbonate aqueous media, Phosphorus, Sulfur, and Silicon, 2009, 184,2553–2559. SCI<br/>   45.Mingtiao Cai, Jiuxi Chen, Xiaobo Huang, Miaochang Liu, Jinchang Ding,* Huayue Wu,* Synthesis of fluorinated β-carbolines by one-pot reaction, J. Chem. Res. 2008, 296-298. SCI<br/>   46.Jinchang Ding,* Rong Xu, Miaochang Liu, Xi’an Chen, Huayue Wu,* Gallium triiodide as a highly efficient and mild catalyst for the diethyl acetalization of carbonyl compounds J. Indian Chem. Soc. 2008, 85, 566-568. SCI<br/>   47.Changming Qin, Huayue Wu,* Jiuxi Chen, Miaochang Liu, Jiang Cheng,* Weike Su, Jinchang Ding, Palladium-catalyzed aromatic esterification of aldehydes with organoboronic acids and molecular oxygen, Org. Lett. 2008, 10, 1537-1540. SCI-TOP<br/>   48.Qiang Zhang, Jiuxi Chen, Miaochang Liu, Huayue Wu,* Jiang Cheng,* Changming Qin, Weike Su, Jinchang Ding, Palladium-catalyzed addition of arylboronic acids to N-tosylarylimines, Synlett 2008, 935-939. SCI-TOP<br/>   49.Changming Qin, Jiuxi Chen, Huayue Wu,* Jiang Cheng, Qiang Zhang, Bing Zuo, Weike Su, Jinchang Ding, One-pot synthesis of diaryl ketones from aldehydes via palladium-catalyzed reaction with aryl boronic acids, Tetrahedron Lett. 2008, 49, 1884–1888. SCI-TOP<br/>   50.Jiuxi Chen, Dengze Wu, Fei He, Miaochang Liu, Huayue Wu,* Jinchang Ding, Weike Su*, Gallium(III) triflate-catalyzed one-pot selective synthesis of 2,3-dihydro-quinazolin-4(1H)-ones and quinazolin-4(3H)-ones, Tetrahedron Lett. 2008, 49, 3814-3818. SCI-TOP<br/>   51.Xian Chen, Huayue Wu,* Rong Xu, Miaochang Liu, Jinchang Ding, Weike Su, Gallium Trichloride–promoted highly regioselective ring opening of epoxides with NH4SCN and NaN3 in water, Synth. Commun. 2008, 38, 1855–1865. SCI<br/>   52.Changfu Zhang, Jiuxi Chen, Xiaochun Yu, Xian Chen, Huayue Wu,* Jianping Yu, B2O3/Al2O3 as an efficient and recyclable catalyst for the synthesis of β-amino alcohols under solvent-free conditions, Synth. Commun. 2008, 38, 1875–1887. SCI<br/>   53.Fei He, Huayue Wu, Jiuxi Chen, Weike Su, Unexpectedly high activity of Zn(OTf)2∙6H2O in catalytic Friedel–Crafts acylation reaction, Synth. Commun. 2008, 38, 255–264. SCI<br/>   54.Jiuxi Chen, Miaochang Liu, Xiaoliang Yang, Jinchang Ding, Huayue Wu,* Indium(III)-catalyzed synthesis of N-substituted pyrroles under solvent-free conditions, J. Braz. Chem. Soc. 2008, 19, 877-883. SCI<br/>   55.Jiuxi Chen, Weike Su,* Huayue Wu,* Miaochang Liu, Can Jin, Eco-friendly synthesis of 2,3-dihydroquinazolin-4(1H)-ones in iionic liquids or ionic liquid–water without additional catalyst, Green Chem. 2007, 9, 972-975. SCI-TOP<br/>   56.Xian Chen, Changfu Zhang, Huayue Wu,* Xiaochun Yu, Weike Su*, Jiang Cheng, Solvent-free synthesis of β-hydroxy esters and β-amino esters by indium-mediated Reformatsky reaction, Synthesis 2007, 3233-3239. SCI-TOP<br/>   57.Changming Qin, Huayue Wu,* Jiang Cheng,* Xi’an Chen, Miaochang Liu, Weiwei Zhang, Weike Su, Jinchang Ding, The palladium-catalyzed addition of aryl- and heteroarylboronic acids to aldehydes, J. Org. Chem. 2007, 72, 4102-4107. SCI-TOP<br/>   58.Jiuxi Chen, Huayue Wu,* Weike Su, A facile synthesis of 2,3-dihydro-2-aryl-4(1H)-quinazolinones catalyzed by scandium(III) triflate, Chin. Chem. Lett. 2007, 18, 536–538. SCI-E<br/>   59.Xian Chen, Huayue Wu,* Weike Su, Rong Xu, Miaochang Liu, Jinchang Ding, Active metallic indium-mediated ring-opening of epoxides with diphenyl diselenides: a novel one-pot synthesis of β-hydroxy selenides in aqueous media, J. Chem. Res. 2007, 325-327. SCI<br/>   60.Weike Su,* Jiuxi Chen, Huayue Wu, Can Jin, A general and efficient method for the selective synthesis of α-hydroxy sulfides and β-hydroxy sulfoxides catalyzed by gallium(III) triflate, J. Org. Chem. 2007, 72, 4524-4527. SCI-TOP<br/>   61.Jiuxi Chen, Huayue Wu, Can Jin, Xingxian Zhang, Yuanyuan Xie, Weike Su,* Highly regioselective ring-opening of epoxides with thiophenols in ionic liquids without the use of any catalyst, Green Chem. 2006, 8, 330–332. SCI-TOP<br/>   62.Jiuxi Chen, Huayue Wu, Zhiguo Zheng, Can Jin, Xingxian Zhang, Weike Su,* An approach to the Paal–Knorr pyrroles synthesis catalyzed by Sc(OTf)3 under solvent-free conditions, Tetrahedron Lett. 2006, 47, 5383–5387. SCI-TOP<br/> <br/>   主要项目 <br/> </strong>  1.《基于氢键活化环氧化物的不对称开环反应研究》国家自然科学基金( 21072153),2011年1月-2013年12月,项目负责人<br/>   2.《绿色化学合成技术及应用创新团队》浙江省科技创新团队(2009R50002),2010年7月-2012年7月,子课题负责人<br/>   3.《头孢、碳青霉烯系列原料药的绿色合成技术集成与示范》,国家“十一五”科技支撑计划(2007BAQ00155),2007年8月-2010年12月,国家科技部,第二负责人<br/>   4.《华基化工股份有限公司全面合作协议》,横向委托,2009年3月-2012年3月,负责人<br/>   5.《头孢系列活性酯的绿色合成技术开发》,浙江省绿色化工重大专项(2006C11022),2006年6月,浙江省科学技术厅,子课题负责人<br/>   6.《纺织助剂十八烷基乙烯脲的清洁生产技术开发》浙江省科技计划项目(2005C31036),2005年01月,浙江省科学技术厅,项目负责人<br/>   7.《聚对芳撑乙炔类高聚物的合成、修饰及表征》,浙江省自然科学基金(Y405015),2006年01月,项目负责人<br/>   8.《医药中间体2-氯苯并咪唑的合成研究》,浙江省科技计划项目(2003C31026),2003年01月,浙江省科学技术厅,项目负责人<br/>   9.《吡咯酯的合成研究》,横向委托项目,2004年12月,项目负责人<br/>   10.《辣椒素微胶囊的研制及其在电线、电缆护套线防鼠咬应用研究》,横向委托项目,2004年12月,项目负责人<br/>   11.《炔草酯原药研制开发》,招标项目,2004年11月,项目负责人<br/>   12.《邻乙氧基苯酚的高效节能、连续化清洁生产工艺研发》,横向委托,2004年11月,项目负责人<br/> <br/>   专利 <br/> </strong>  1.吴华悦,黄小波,吴登泽,苏为科“一种2-氯苯并咪唑的化学合成方法”发明专利,ZL200710172683.9(2007-12-21)已授权<br/>   2.吴华悦,吴登泽,黄小波,苏为科“一种2-羟基苯并咪唑的化学合成方法”发明专利,ZL200710172682.4(2007-12-21)已授权<br/>   3.吴华悦,陈久喜,苏为科,刘妙昌“一种喹唑啉酮类化合物的合成方法”发明专利,ZL200710156597.9(2007-11-9)已授权<br/>   4.吴华悦,何 飞,苏为科,陈久喜“一种黄酮类化合物的化学合成方法”发明专利,ZL200810060946.1(2008-04-08)已授权<br/> <br/>   学术获奖 <br/> </strong>  1.浙江省科学技术奖三等奖,绿色化学技术及金属试剂在有机合成中的应用研究,2009年,排名第一<br/>   2.浙江省科学技术奖三等奖,含氮杂环及β-羟基类化合物的绿色合成研究,2010年,排名第四<br/> <br/>   *如果发现导师信息存在错误或者偏差,欢迎随时与我们联系,以便进行更新完善。联系方式</a></p> </div>


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